In the church at Antioch there are prophets and teachers, among them Barnabas and Saul. While they worship the Lord and fast, the Holy Spirit says to set apart Barnabas and Saul for the work to which he has called them. After fasting and praying, they lay their hands on them and send them off. They sail to Cyprus, where they preach in the synagogues at Salamis, with John Mark as their helper.
At Paphos, a Jewish magician, Bar-Jesus or Elymas, opposes them and tries to turn the proconsul Sergius Paulus away from the faith. Saul, also called Paul, filled with the Spirit, declares that Elymas will be blind for a time, and at once darkness falls on him. The proconsul believes, amazed at the teaching about the Lord. At Perga in Pamphylia, John Mark leaves them and returns to Jerusalem.
In Pisidian Antioch, on the Sabbath, the synagogue leaders invite them to speak after the reading of the law and the prophets. Paul surveys Israel's history up to David, from whose offspring came Jesus as Savior. The people of Jerusalem condemned him without knowing it, fulfilling the prophets, but God raised him. Paul announces that through Jesus forgiveness of sins is proclaimed, and that everyone who believes is freed from everything from which the law of Moses could not free them.
The next Sabbath almost the whole city gathers to hear the word. The Jews, filled with jealousy, contradict and blaspheme. Paul and Barnabas declare that the word had to be spoken to them first, but since they reject it, they turn to the Gentiles, who rejoice, and all who were appointed to eternal life believe. The Jews stir up devout women and the leading men and drive them out. They shake off the dust from their feet and go to Iconium, and the disciples are filled with joy and the Holy Spirit.