The messenger declares that in the first year of Darius the Mede he himself stood up to support and strengthen him. He announces that three more kings will arise in Persia and a fourth far richer than all, who by his wealth will stir up everyone against the kingdom of Greece. Then a mighty king will arise, rule with great dominion and do as he wills; but at the height of his power his kingdom will be broken and divided toward the four winds of heaven, not to his descendants.
The following verses describe a series of clashes between the king of the south and the king of the north, that is, the rulers of the kingdoms that arose to the south and north of Israel. There are marriage alliances that fail, invasions and retreats, and the glorious land, Israel, comes several times under the control of one or the other. Many interpreters see in these lines the history of the kingdoms that arose from the division of Alexander's empire, the Ptolemies of Egypt and the Seleucids of Syria.
From verse 21 a contemptible man appears, who takes the kingdom by flattery and intrigue, breaks even a prince of the covenant and rises against the holy covenant. His forces profane the sanctuary, take away the regular sacrifice and set up the abomination that makes desolate. But the people who know their God will stand firm and take action; the wise will instruct many, though some will fall, and this serves to refine them until the time of the end.
From verse 36 a king is described who does as he wills, exalts himself above every god and speaks astonishing things against the God of gods. At the time of the end the king of the south will attack him and the king of the north will rush at him like a whirlwind. He will enter the glorious land and stretch out his hand over many countries, but in the end he will come to his end with no one to help him.