The poem opens with a general statement: whoever dwells in the shelter of the Most High will rest in the shadow of the Almighty. In verse 2 a personal voice answers: the Lord is my refuge and my fortress, my God, in whom I trust. From verse 3 the psalm speaks to that believer as you and lists dangers: the snare of the fowler, the deadly pestilence, the terror of the night, the arrow by day, the sickness that stalks in darkness and the destruction at noonday. God covers him like a bird with its wings, and his faithfulness is a shield and rampart.
Verse 7 says a thousand may fall at the believer's side without the evil reaching him, and he will see the punishment of the wicked. Verses 9 and 10 repeat the foundation: because he has made the Lord his refuge and dwelling place, no disaster will come near his tent. Verses 11 and 12 add that God will command his angels to guard him in all his ways, so that his foot does not strike a stone. He will tread on the lion and the adder.
In verses 14-16 the speaker changes: it is God himself who promises to rescue the one who holds fast to him in love, set him on high because he knows his name, answer him when he calls, be with him in trouble, deliver and honor him. He will satisfy him with long life and show him his salvation.